A genome-wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans.
Y ChenMathilde AndréKaustubh AdhikariM BlinBetty BonfanteJavier Mendoza-RevillaM Fuentes-GuajardoS PalmalJuan Camilo Chacón-DuqueM HurtadoV VillegasV GranjaC JaramilloW AriasR B LozanoP Everardo-MartínezJ Gómez-ValdésH Villamil-RamírezC C S de CerqueiraT HünemeierV RamalloR Gonzalez-JoséL Schüler-FacciniM-C BortoliniV Acuña-AlonzoS Canizales-QuinterosC GalloG PolettiG BedoyaF RothhammerD BaldingDesmond J TobinSi-Jia WangPierre FauxAndrés Ruiz-LinaresPublished in: The British journal of dermatology (2021)
We replicate the association of wrinkling with variants in SLC45A2, IRF4 and MC1R reported in Europeans. We identify VAV3 and SLC30A1 as two novel candidate genes impacting on wrinkling and mole count, respectively. We provide the first evidence that SLC45A2 influences mole count, in addition to variants in this gene affecting melanoma risk in Europeans.