Loop diuretics inhibit kynurenic acid production and kynurenine aminotransferases activity in rat kidneys.
Izabela ZakrockaKatarzyna M Targowska-DudaTomasz KockiWaldemar TurskiEwa M UrbańskaWojciech ZałuskaPublished in: Pharmacological reports : PR (2024)
Our study reveals that loop diuretics may decrease KYNA synthesis in rat kidneys in vitro. The presented results warrant further research in the context of KYN pathway activity regulation by loop diuretics.
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