Ru-, Rh- and Ir-Catalyzed Enantioselective sp 3 C-H Functionalization.

The development of novel methodologies that enable the construction of complex chiral molecular scaffolds in an atom and step-economic manner has always been an area of immense interest and significant synthetic value. The transition metal-catalyzed enantioselective sp 3 C-H activation and functionalization reactions serve as an expeditious means for introducing diverse functionalities in a straightforward manner. However, controlling the chemo- and stereoselectivity of these reactions is a significant challenge owing to their ubiquity and low reactivity. In this review, we present a comprehensive account on the recent advances in inter- and intramolecular asymmetric sp 3 C-H bond functionalization utilizing ruthenium, rhodium, and iridium catalysts and get insights into the mechanistic aspects of these transformations.