Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study.
Marijn H A GroenFons J B SliekerA VinkG J de BorstM V SimonsE S EbbiniP A DoevendansC E V B HazenbergRené van EsPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2021)
HIFU/DMUA therapy successfully targeted the vessel walls of healthy porcine arteries, without causing endothelial damage or other vascular complications. Therefore, this therapy can be safely applied to healthy arterial walls in animals. Future studies should focus on safety and dose-finding in atherosclerotic diseased arteries.