Exosome-shuttled mitochondrial transcription factor A mRNA promotes the osteogenesis of dental pulp stem cells through mitochondrial oxidative phosphorylation activation.

Jia GuoFeng ZhouZhi LiuYuan CaoWanming ZhaoZheru ZhangQiming ZhaiYan JinBei LiFang Jin

Published in: Cell proliferation (2022)

Consequently, exosomes strengthened bone regeneration of DPSCs through the activation of mitochondrial aerobic metabolism. Our study provides a new potential strategy to improve DPSC-based bone regenerative treatment.

Keyphrases

stem cells
bone regeneration
oxidative stress
transcription factor
mesenchymal stem cells
cell therapy
bone mineral density
high intensity
risk assessment
postmenopausal women
body composition
bone loss
climate change
soft tissue
combination therapy
tissue engineering
bone marrow