Utility of the ALSFRS-R for predicting ALS and comorbid disease neuropathology: The Veterans Affairs Biorepository Brain Bank.
Leigh E ColvinZachariah W FosterThor D SteinManisha Thakore-JamesMohammad Kian SalajeghehKendall CarrKeith R SpencerNazifa Abdul RaufLatease AdamsJames G AverillSean E WalkerIan RobeyVictor E AlvarezBertrand R HuberAnn C McKeeNeil W KowallChristopher B BradyPublished in: Muscle & nerve (2022)
These results suggest that discrete patterns of motor dysfunction based on ALSFRS-R subdomain scores are related to postmortem neuropathology. Findings support use of ALSFRS-R subdomain scores to capture the heterogeneity of clinical presentation and disease progression in ALS, and may assist researchers in identifying endophenotypes for separate assessment in clinical trials.