A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE).
Mehdi Fazel-NajafabadiLoren L LoogerHarikrishna Reddy-RallabandiSwapan K NathPublished in: medRxiv : the preprint server for health sciences (2023)
We demonstrate and validate post-GWAS strategies for utilizing multi-dimensional data to prioritize likely causal variants with cognate gene targets underlying SLE pathogenesis. Our results provide a catalog of significantly SLE-associated SNPs and loci, target genes, and likely biochemical mechanisms, to guide experimental characterization.