AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis.
Xiangdong LiuLiang ZhaoYao GaoYanting ChenQiyu TianJun Seok SonSong Ah ChaeJeanene Marie de AvilaMei-Jun ZhuMin DuPublished in: Journal of cachexia, sarcopenia and muscle (2022)
These data suggest that AMPK is a key mediator of FAPs apoptosis, and its inhibition due to obesity results in fibrosis of regenerated muscle.
Keyphrases
- protein kinase
- skeletal muscle
- insulin resistance
- stem cells
- metabolic syndrome
- oxidative stress
- weight loss
- type diabetes
- endoplasmic reticulum stress
- electronic health record
- cell death
- big data
- liver fibrosis
- cell cycle arrest
- machine learning
- body mass index
- artificial intelligence
- deep learning
- signaling pathway