Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes.
William ChangMichelle LajkoAmani A FawziPublished in: PloS one (2018)
Epiretinal membrane formation in proliferative diabetic retinopathy involves higher tissue levels of endothelin-1 and fibroblastic activity. Furthermore, endothelin-1, endothelial and fibroblastic staining appear to be correlated, suggestive of endothelial-to-mesenchymal transition in proliferative diabetic retinopathy.