Co-existent pilocytic astrocytoma with acute B-cell leukemia within the cerebellum.
Richard A HickmanRebecca Leeman-NeillMarc RosenblumRichard AndersonJames GoldmanPublished in: Neuropathology : official journal of the Japanese Society of Neuropathology (2019)
Pilocytic astrocytomas are the commonest childhood brain tumor. They are typically benign and usually are solitary neoplasms. To our knowledge, only one report of a pilocytic astrocytoma with leukemia has been previously issued. We herein describe the first case with documented histopathology of a 2-year-old boy who had a cerebellar pilocytic astrocytoma co-localized with an acute B-lymphoblastic leukemia. We speculate that chemotactic migration of leukemic cells to the pilocytic astrocytoma may be partly mediated through vascular endothelial growth factor (VEGF) and VEGF receptors.
Keyphrases
- vascular endothelial growth factor
- acute myeloid leukemia
- liver failure
- endothelial cells
- bone marrow
- respiratory failure
- induced apoptosis
- healthcare
- aortic dissection
- oxidative stress
- cell cycle arrest
- intensive care unit
- cell death
- cell proliferation
- extracorporeal membrane oxygenation
- rare case
- acute respiratory distress syndrome