RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine.

Michael G Miskelly Andreas Lindqvist Elena Piccinin Alexander Hamilton Elaine CowanBent-Johnny NergårdRita Del Giudice Mtakai Ngara Luis Rodrigo Cataldo Dmytro KryvokhyzhaPetr VolkovAlbert G Linden Isabella Artner Jens O Lagerstedt Lena Eliasson Emma Ahlqvist Antonio Moschetta Jan Hedenbro Nils Wierup

Published in: Diabetologia (2023)

RYGB caused robust alterations in the jejunal transcriptome, with genes involved in cholesterol biosynthesis being most affected. Our data highlight SCD as an RYGB-regulated L cell constituent that regulates the production and secretion of GLP-1.

Keyphrases

single cell
roux en y gastric bypass
gastric bypass
rna seq
weight loss
cell therapy
endothelial cells
obese patients
gene expression
transcription factor
stem cells
electronic health record
bariatric surgery
big data
induced pluripotent stem cells
low density lipoprotein
small bowel