Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.

Hannah Knight Giancarlo AbisManpreet KaurHannah L H Green Susanne KrasemannKristin HartmannSteven Lynham James E Clark Lan Zhao Clemens Ruppert Astrid Weiss Ralph Theo Schermuly Philip Eaton Olena Rudyk

Published in: Circulation research (2023)

A novel disulfide bond in cyclin D-CDK4 acts as a rapid switch to inhibit kinase activity and halt cell proliferation. This oxidative modification forms at a critical cysteine residue, which is unique to CDK4, offering the potential for the design of a selective covalent inhibitor predicted to be beneficial in PH.

Keyphrases

cell cycle
cell proliferation
pulmonary hypertension
pi k akt
tyrosine kinase
cell death
protein kinase
signaling pathway
fluorescent probe
human health
climate change
loop mediated isothermal amplification
electron transfer