Genetic Ablation of Pyruvate Dehydrogenase Kinase Isoform 4 Gene Enhances Recovery from Hyperoxic Lung Injury: Insights into Antioxidant and Inflammatory Mechanisms.

Keisuke WatanabeAkie KatoHiroyuki AdachiAtsuko NoguchiHirokazu AraiMasato ItoFumihiko NambaTsutomu Takahashi

Published in: Biomedicines (2024)

Newborn PDK4-/- mice exhibited notable recovery from hyperoxia-induced lung injury, suggesting the potential protective role of PDK4 depletion in mitigating lung damage.

Keyphrases

oxidative stress
diabetic rats
genome wide
copy number
high glucose
high fat diet induced
anti inflammatory
tyrosine kinase
type diabetes
radiofrequency ablation
metabolic syndrome
atrial fibrillation
skeletal muscle
climate change