Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease.
Scott B LaffoonJames D DoeckeAnne M RobertsJennifer A VanceBenjamin D ReevesKelly K PertileRebecca L RumbleChris J FowlerBrett TrounsonDavid AmesRalph MartinsAshley I BushColin L MastersPaul A GriecoEdward A DratzBlaine R RobertsPublished in: Proteome science (2022)
This demonstrates that further development of mass spectrometry assays is needed to capture the isoform complexity that exists in theses biological samples. However, this study indicates that a peripheral protein signature has potential to aid in the characterization of AD.