Proenkephalin and the risk of new-onset heart failure: data from prevention of renal and vascular end-stage disease.
Johanna Elisabeth EmmensJozine M Ter MaatenFrank P BrouwersLyanne M KienekerKevin DammanOliver HartmannJanin SchulteStephan J L BakkerRudolf A de BoerAdriaan A VoorsPublished in: Clinical cardiology (2021)
In the general population, higher PENK concentrations were associated with lower eGFR and higher NT-proBNP concentrations. Higher PENK concentrations were not independently associated with new-onset HFrEF and HFpEF and mainly confounded by eGFR.