Dietary prophage inducers and antimicrobials: toward landscaping the human gut microbiome.
Lance BolingDaniel A CuevasJuris A GrasisHan Suh KangBen KnowlesKyle LeviHeather MaughanKatelyn McNairMaria Isabel RojasSavannah E SanchezCameron SmurthwaiteForest RohwerPublished in: Gut microbes (2020)
The approximately 1011 viruses and microbial cells per gram of fecal matter (dry weight) in the large intestine are important to human health. The responses of three common gut bacteria species, and one opportunistic pathogen, to 117 commonly consumed foods, chemical additives, and plant extracts were tested. Many compounds, including Stevia rebaudiana and bee propolis extracts, exhibited species-specific growth inhibition by prophage induction. Overall, these results show that various foods may change the abundances of gut bacteria by modulating temperate phage and suggests a novel path for landscaping the human gut microbiome.
Keyphrases
- human health
- endothelial cells
- risk assessment
- induced pluripotent stem cells
- induced apoptosis
- body mass index
- climate change
- microbial community
- weight loss
- physical activity
- signaling pathway
- pseudomonas aeruginosa
- cell death
- cell proliferation
- oxidative stress
- weight gain
- ionic liquid
- gram negative
- plant growth
- pi k akt