Immunogenomic profiles associated with response to neoadjuvant chemoradiotherapy in patients with rectal cancer.

Takashi AkiyoshiN TanakaK KiyotaniO GotohN YamamotoK ObaYosuke FukunagaM UenoS Mori

Published in: The British journal of surgery (2019)

Pre-CRT neoantigen-specific CD8+ T cell priming may be a key event in CRT responses where immune checkpoint molecules could be useful targets to enhance tumour regression.

Keyphrases

rectal cancer
locally advanced
cardiac resynchronization therapy
left ventricular
heart failure
radiation therapy
atrial fibrillation