Haptoglobin gene polymorphism and iron profile in sickle cell disease patients with inflammation in Yaounde, Cameroon.
Romaric De Manfouo TuonoJosué Louokdom SimoProsper Cabral Biapa NyaJean Paul ChedjouChristian Bernard Kengne FotsingBernard Claude ChetchaCalvino Fomboh TahClaude Tagny TayouWilfried Fon MbatchamConstant Anatole PiemePublished in: Molecular genetics & genomic medicine (2023)
This study demonstrates a higher frequency of genotype HP 1-1 followed by the HP 2-2 genotype in patients with major sickle cell syndromes. However, a larger proportion of patients with genotype HP 2-2 are associated with hematological profile disorders, inflammation, and dysregulation of iron metabolism. Then, the haptoglobin polymorphism contributes to the severity of major sickle cell syndromes.