Detection of Multiple HPV Types in Liquid Biopsies of Cervical Neoplasia.

Johanna HerbstVanessa VohlMaroje KrajinaMarkus LeffersJolanthe KropidlowskiKatharina PrieskeAnna JaegerLeticia Oliveira FerrerBarbara SchmalfeldtYvonne GoyEike BurandtKlaus PantelCaren VollmertAlexander SartoriLinn WoelberKatharina EffenbergerHarriett Wikman

Published in: Clinical chemistry (2024)

This proof-of-concept paper shows that the described assay produces reliable results for detecting HPV types in a multiplex mass spectrometry-based assay in cervical smear and cfDNA with high specificity and sensitivity in both cohorts. The assay shows potential for liquid biopsy-based applications in monitoring cervical cancer progression.

Keyphrases

high throughput
high grade
mass spectrometry
real time pcr
ionic liquid
liquid chromatography
pulmonary tuberculosis
high resolution
climate change
high performance liquid chromatography
fine needle aspiration