Short lookback periods causing exaggerated stroke risk estimates in atrial fibrillation may expose patients to unnecessary anticoagulant treatment.
Leif FribergPublished in: Pharmacoepidemiology and drug safety (2019)
Short lookback periods underestimate comorbidity, cause high-risk patients to be misclassified as low risk, and overestimate stroke risk at CHA2 DS2 -VASc 1. This may lead to unnecessary anticoagulant treatment of true low-risk patients. Transparency regarding lookback periods is essential for interpretation and comparison of registry studies.
Keyphrases
- acute coronary syndrome
- percutaneous coronary intervention
- atrial fibrillation
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- heart failure
- prognostic factors
- coronary artery disease
- venous thromboembolism
- left atrial
- catheter ablation
- patient reported outcomes
- mitral valve
- oral anticoagulants
- combination therapy
- subarachnoid hemorrhage
- patient reported
- breast cancer risk