Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice.
Giovanni CaocciOlga MulasElisabetta AbruzzeseAlessandra IurloMario AnnunziataEster Maria OrlandiSara GalimbertiGianni BinottoNicola SgherzaLuigia LucianoBruno MartinoAntonella Russo RossiMassimiliano BonifacioClaudio FozzaMalgorzata Monika TrawinskaDaniele CattaneoChiara ElenaClaudia BaratèFiorenza De GregorioMatteo MolicaGiorgio La NasaRobin FoàMassimo BrecciaPublished in: Annals of hematology (2019)
There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessment, based on sex, age, smoking habits, systolic blood pressure, and total cholesterol levels. The 40-month cumulative incidence of CV-AEs was 25.2 ± 8.1%. Patients with the SCORE of high-very high showed a significantly higher incidence of CV-AEs (55 ± 12.9% vs 9 ± 9.5%; p = 0.002). Overall, 9 CV-AEs were reported, with 2 deaths attributed to CV-AE. In conclusion, the SCORE assessment before starting treatment is helpful in identifying CV-AE high-risk patients during bosutinib treatment.
Keyphrases
- chronic myeloid leukemia
- blood pressure
- risk factors
- end stage renal disease
- healthcare
- primary care
- heart failure
- newly diagnosed
- ejection fraction
- coronary artery disease
- chronic kidney disease
- coronary artery
- peritoneal dialysis
- emergency department
- prognostic factors
- skeletal muscle
- metabolic syndrome
- aortic valve
- combination therapy
- clinical evaluation
- low density lipoprotein