Takayasu arteritis risk locus in IL6 represses the anti-inflammatory gene GPNMB through chromatin looping and recruiting MEF2-HDAC complex.

Published in: Annals of the rheumatic diseases (2019)

Takayasu arteritis risk locus in IL6 might increase disease susceptibility by suppression of the anti-inflammatory gene GPNMB through chromatin looping and recruitment of MEF2-HDAC epigenetic repressive complex. Our data highlight long-range chromatin interactions in functional genomic and epigenomic studies in autoimmunity.

Keyphrases

genome wide
anti inflammatory
gene expression
copy number
dna damage
dna methylation
transcription factor
histone deacetylase
genome wide identification
oxidative stress
genome wide analysis