Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia.

Xiang WeiLina WangJie HuaXiao-Hong JinFuhai JiKe PengBin ZhouJianping YangXiao-Wen Meng

Published in: Journal of neuroinflammation (2021)

These findings demonstrate that inhibiting BDNF/TrkB.T1 reduced inflammation, decreased neuronal hyperexcitability, and improved mechanical allodynia through regulating the ASIC3 signaling pathway in DRGs, which may provide a novel therapeutic target for patients with PHN.

Keyphrases

signaling pathway
neuropathic pain
pi k akt
oxidative stress
stress induced
spinal cord
induced apoptosis
diabetic rats
epithelial mesenchymal transition
high glucose
spinal cord injury
endothelial cells
brain injury
binding protein
blood brain barrier