DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.
Loubna AkhabirRanda StringerDipika DesaiPiush J MandhaneMeghan B AzadTheo J MoraesPadmaja SubbaraoStuart E TurveyGuillaume ParéSonia S Anandnull nullPublished in: BMC genomics (2022)
Maternal smoking during pregnancy and gestational age are strongly associated with differential methylation in offspring cord blood, as assessed in the EWAS literature and our birth cohorts. There are a limited number of reported methylation sites associated in more than two independent studies related to pregnancy. Additional large studies of diverse populations with fine phenotyping are needed to produce robust epigenome-wide data in order to further elucidate the effect of intrauterine exposures on the infants' methylome.
Keyphrases
- cord blood
- dna methylation
- gestational age
- birth weight
- preterm birth
- genome wide
- air pollution
- gene expression
- pregnancy outcomes
- public health
- case control
- healthcare
- systematic review
- copy number
- electronic health record
- big data
- smoking cessation
- health information
- pregnant women
- skeletal muscle
- machine learning
- physical activity
- body mass index
- adipose tissue
- social media