Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma.

Yinfei TanEleonora SementinoMitchell CheungSuraj PeriCraig W MengesAnna-Mariya KukuyanTing ZhangVladimir KhazakLauren A FoxEric A RossSuresh RamanathanSuresh C JhanwarRaja M FloresSiddharth BalachandranJoseph R Testa

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data suggest that RIPK3 acts as a tumor suppressor in malignant mesothelioma by triggering necroptosis and that epigenetic silencing of RIPK3 by DNA methylation impairs necroptosis and contributes to chemoresistance and poor survival in this incurable disease.

Keyphrases

dna methylation
gene expression
genome wide
copy number
electronic health record
big data
machine learning
data analysis
deep learning