Quantifying the Impact of Nasopharyngeal Specimen Quality on Severe Acute Respiratory Syndrome Coronavirus 2 Test Performance.
Melissa Richard-GreenblattMatthew J ZieglerValerie BrombergElizabeth HuangHatem AbdallahPam TolomeoEbbing LautenbachLaurel GlaserBrendan J KellyPublished in: Open forum infectious diseases (2021)
Variability in NP specimen quality significantly impacts the performance of clinical SARS-CoV-2 assays, and caution should be taken when interpreting quantitative SARS-CoV-2 Ct results. If unrecognized, low-quality NP specimens, which are characterized by a low level of amplifiable human DNA target, may limit the successful application of SARS-CoV-2 Ct values to direct infection control and public health interventions.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- public health
- computed tomography
- coronavirus disease
- quality improvement
- endothelial cells
- image quality
- dual energy
- contrast enhanced
- high resolution
- physical activity
- high throughput
- positron emission tomography
- cell free
- magnetic resonance imaging
- circulating tumor
- magnetic resonance
- mass spectrometry
- pet ct