CD8 Encephalitis: A Diagnostic Dilemma.
Rohan SharmaThomas SpradleyMorgan CampbellShubham BiyaniPulkit SinghalHisham ElkhiderKrishna NalleballeMurat GokdenManoj KumarNidhi KapoorPublished in: Diagnostics (Basel, Switzerland) (2022)
CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and 'viral escape' phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HIV who developed CD8 encephalitis following Herpes simplex encephalitis. He had persistent encephalopathy for several weeks with status epilepticus and agitated delirium, and diagnosis remained elusive until a brain biopsy confirmed the diagnosis.
Keyphrases
- hiv infected
- induced apoptosis
- antiretroviral therapy
- cell cycle arrest
- nk cells
- human immunodeficiency virus
- hiv positive
- endoplasmic reticulum stress
- cell death
- signaling pathway
- sars cov
- hepatitis c virus
- multiple sclerosis
- hiv aids
- ultrasound guided
- blood brain barrier
- south africa
- subarachnoid hemorrhage
- fine needle aspiration