TRPV4 Antagonism Prevents Mechanically Induced Myotonia.

Chris DupontKevin NovakKirsten DenmanJessica H MyersJeremy M SullivanPhillip V WalkerNicklaus L BrownDavid R LadleLaurent BogdanikCathleen M LutzAndrew A VossCharlotte J SumnerMark M Rich

Published in: Annals of neurology (2020)

These data demonstrate that there are distinct molecular mechanisms triggering electrically induced and mechanically induced myotonia. Our data indicates that activation of TRPV4 during muscle contraction plays an important role in triggering myotonia in vivo. Elimination of mechanically induced myotonia by TRPV4 inhibition offers a new approach to treating myotonia. ANN NEUROL 2020;88:297-308.

Keyphrases

high glucose
diabetic rats
oxidative stress
skeletal muscle
neuropathic pain
spinal cord injury
mouse model
data analysis
neural network