Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.

Jinye LiangLei LiXuanxuan JinBingxin XuLinyu PiShangyun LiuWei ZhuCong ZhangBing LuanLulu GongChao Zhang

Published in: Endocrine (2018)

This is the first dedicated description of single-cell transcriptome signature of Mrap2, Mc3r, and Mc4r in the central nerve system and the first evidence describing the unique dimer formation, conformational change, and pharmacological effect of MRAP2 mutations on MC3R signaling.

Keyphrases

single cell
rna seq
endothelial cells
molecular dynamics

gene expression
copy number
binding protein

high throughput
induced pluripotent stem cells
molecular dynamics simulations

protein protein
amino acid
dna methylation