A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network.
Emma G MillsMelissa J MartinTing L LuoAna C OngRosslyn MaybankBrendan W CoreyCasey HarlessLan N PrestonJoshua A Rosado-MendezScott B PrestonYoon I KwakMichael G BacklundJason W BennettPatrick T Mc GannFrancois LebretonPublished in: Genome medicine (2022)
By coupling in-depth genomic characterization with a complete sampling of clinical isolates for a full year, this study provides a rare and contemporary survey on the epidemiology and spread of E. coli in a large US healthcare network. While surveillance and infection control efforts often focus on ESBL and MDR lineages, our findings reveal that non-MDR isolates represent a large burden of infections, including those of predicted nosocomial origins. This increased awareness is key for implementing effective WGS-based surveillance as a routine technology for infection control.
Keyphrases
- escherichia coli
- healthcare
- klebsiella pneumoniae
- multidrug resistant
- public health
- acinetobacter baumannii
- risk factors
- copy number
- quality improvement
- drug resistant
- methicillin resistant staphylococcus aureus
- optical coherence tomography
- clinical practice
- biofilm formation
- single cell
- staphylococcus aureus
- room temperature
- pseudomonas aeruginosa
- genetic diversity
- cystic fibrosis