Drug-DNA complexation as the key factor in photosensitized thymine dimerization.

M Consuelo Cuquerella Virginie Lhiaubet-ValletMiguel A MirandaFrancisco Bosca

Published in: Physical chemistry chemical physics : PCCP (2018)

The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals.

Keyphrases

dna damage
circulating tumor
cell free
single molecule
photodynamic therapy
oxidative stress
dna repair
high throughput
nucleic acid
circulating tumor cells
cerebral ischemia
adverse drug
solid state
blood brain barrier