Use of gastric acid-suppressive agents increases the risk of dementia in patients with upper gastrointestinal disease: A population-based retrospective cohort study.
Hsiu-Chen LinKuan-Tzu HuangHsiu-Li LinYow-Sheng UangYi HoJoseph Jordan KellerLi-Hsuan WangPublished in: PloS one (2021)
Our results demonstrate an increased risk of dementia in patients with UGID receiving gastric acid-suppressive agents, including PPIs and H2RAs, and the use of PPIs was associated with a significantly greater risk than H2RA use.