Molecular pathology of skin adnexal tumors.

Recent discoveries have revealed diverse oncogenic drivers and tumor suppressor alterations in this class of tumors, implicating pathways including Ras/MAPK, PI3K, YAP/TAZ, beta-catenin, and NF-kappaB. These observations have identified novel markers, such as NUT for poroma and porocarcinoma, and PLAG1 for mixed tumors. Here, we provide a comprehensive overview and update of the molecular findings associated with adnexal tumors of the skin.