Molecular mechanisms of MrgprA3-independent activation of the transient receptor potential ion channels TRPA1 and TRPV1 by chloroquine.
Tabea C FrickeSebastian PantkeBjarne LüttmannFrank G EchtermeyerChristine HerzogMirjam J EberhardtAndreas LefflerPublished in: British journal of pharmacology (2023)
Our data reveal novel pharmacological properties of CQ allowing activation of TRPA1 and TRPV1 via photosensitization as well as intracellular alkalosis. These findings add complexity to the commonly accepted dogma that CQ-induced itch is specifically mediated by MrgprA3 coupling to TRPA1.