Clinical and molecular features of pediatric cancer patients with Lynch syndrome.
Sarah R ScollonMohammad K EldomeryJacquelyn ReutherFrank Y LinSamara L PotterLauren R DesrosiersKenneth L McClainValeria SmithJack Meng-Fen SuRajkumar VenkatramaniJianhong HuViktoriya KorchinaNeda Zarrin-KhamehRichard A GibbsDonna M MuznyChristine EngAngshumoy RoyD Williams ParsonsSharon E PlonPublished in: Pediatric blood & cancer (2022)
Approximately 1% of children with cancer have Lynch syndrome, which is missed with current referral guidelines, suggesting the importance of adding MMR genes to tumor and hereditary pediatric cancer panels. Tumor analysis may provide the first suggestion of an underlying cancer predisposition syndrome and is useful in distinguishing between Lynch syndrome and CMMRD.