MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway.

Tong-Tong LiJie MouYao-Jie PanFu-Chun HuoWen-Qi DuJia LiangYang WangLan-Sheng ZhangDong-Sheng Pei

Published in: Journal of biomedical science (2021)

PAK5 contributed to the sorafenib resistant characteristics of HCC via β-catenin/ABCB1 signaling pathway. Our findings identified the correlation between miR-138-1-3p and PAK5 and the molecular mechanisms of PAK5-mediated sorafenib resistance in HCC, which provided a potential therapeutic target in advanced HCC patients.

Keyphrases

signaling pathway
epithelial mesenchymal transition
end stage renal disease
pi k akt
cell proliferation
induced apoptosis
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
patient reported outcomes
oxidative stress