Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat.
Lina Tariq Al KuryM SmailM A QureshiV SydorenkoAnatoly ShmygolM OzJaipaul SinghFrank Christopher HowarthPublished in: Journal of diabetes research (2018)
The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.
Keyphrases
- glycemic control
- type diabetes
- blood glucose
- oxidative stress
- left ventricular
- cardiovascular disease
- heart failure
- insulin resistance
- blood pressure
- ejection fraction
- end stage renal disease
- wound healing
- newly diagnosed
- chronic kidney disease
- skeletal muscle
- metabolic syndrome
- prognostic factors
- adipose tissue
- peritoneal dialysis
- cardiovascular events
- risk factors
- copy number
- patient reported outcomes
- smooth muscle
- mesenchymal stem cells
- gene expression
- catheter ablation
- cell therapy
- bone marrow