Transcriptome-wide association study for inflammatory bowel disease reveals novel candidate susceptibility genes in specific colon subsites and tissue categories.

Virginia Díez-ObreroFerran Moratalla-NavarroGemma Ibáñez-SanzJordi GuardiolaFrancisco Rodríguez-MorantaMireia Obón-SantacanaAnna Díez-VillanuevaChristopher Heaton DampierMatthew A M DevallRobert Carreras-TorresGraham CaseyVictor Moreno

Published in: Journal of Crohn's & colitis (2021)

These findings provide insight into tissue-specific molecular processes underlying IBD genetic susceptibility. Associated genes could be candidate targets for new therapeutics and should be prioritized in functional studies.

Keyphrases

genome wide
dna methylation
bioinformatics analysis
genome wide identification
gene expression
small molecule
copy number
ulcerative colitis
rna seq
genome wide analysis