A comparative performance evaluation of cephalosporin's drugs for fluoride recognition.
S Saravana KumarS K Ashok KumarSelva Kumar RS K RevathiP S BhargaviPublished in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2023)
In this manuscript, readily available cephalosporin's drugs cefuroxime axetil (L1) cefpdoxime proxetil (L2), and cefditoren pivoxil (L3) possess dihydrothiazine ring as signaling unit, and -NH groups as the binding site were used for the sensing of fluoride (F - ) ions. In the presence of F - , the drug selectively portrayed a naked-eye detectable color change from colorless. The binding constant of 1:1 stoichiometric complex of L1, L2, and L3 with F - was found to be 2.36 × 10 4 M -1 , 2.44 × 10 3 M -1 and 1.02 × 10 4 M -1 respectively. The lowest detection limit (LOD) of F - was found to be 11 µM (209 ppb) with drug L1 and L2. The binding mechanism of the drug with F - was studied by 1 H and 19 F nuclear magnetic resonance (NMR) spectral titration, electrospray ionization mass spectra (ESI-MS) analysis, and density functional theory (DFT) studies. The presence of F - was monitored in various spiked water and Colgate toothpaste samples. Overall, cephalosporin's drug demonstrates a promising potential for the detection of F - ions in the semi-aqueous phase.
Keyphrases
- density functional theory
- magnetic resonance
- ms ms
- drug induced
- molecular dynamics
- gram negative
- emergency department
- drinking water
- quantum dots
- multiple sclerosis
- mass spectrometry
- loop mediated isothermal amplification
- optical coherence tomography
- binding protein
- label free
- real time pcr
- computed tomography
- molecular docking
- molecular dynamics simulations
- transcription factor
- room temperature
- human health
- data analysis