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In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity.

Nobuyoshi FukumitsuSkye Hsin-Hsien YehLeo Garcia Flores IiUday MukhopadhyayDaniel YoungKazuma OgawaHwan-Jeong JeongWilliam TongJuri George Gelovani
Published in: Contrast media & molecular imaging (2018)
[18F]FAHA PET clearly showed increased HDAC activity suggestive of cisplatin neurotoxicity in vivo, which was blocked by SAHA pretreatment.
Keyphrases
  • histone deacetylase
  • pet imaging
  • chemotherapy induced
  • positron emission tomography
  • computed tomography
  • pet ct