Neurofilament light chain in spinal fluid and plasma in multiple system atrophy: a prospective, longitudinal biomarker study.
Wolfgang SingerAnn M SchmeichelDavid M SlettenTonette L GehrkingJade A GehrkingJorge Trejo-LopezMariana D SuarezJennifer K AndersonPamela H BassTimothy G LesnickPhillip A LowPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2023)
These findings confirm NfL-c as a faithful diagnostic marker of MSA, while NfL-p showed less robust diagnostic value. The significant NfL elevation in MSA was found to be remarkably stable over time and was not predictive of clinical disease progression.
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