Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.

Agata KorlatowiczMaciej KuśmiderMarta SzlachtaPaulina PabianJoanna SolichMarta Dziedzicka-WasylewskaFaron-Górecka Agata

Published in: International journal of molecular sciences (2021)

The screening kit we used to study the expression of GPCR-related signal transduction allowed us to select several important genes affected by CLZ. However, the obtained data do not explain the mechanism of action of CLZ that is responsible for reversing KET-induced cognitive impairment.

Keyphrases

cognitive impairment
high glucose
diabetic rats
drug induced
gene expression
pain management
oxidative stress
big data
transcription factor
deep learning
binding protein
chronic pain
long non coding rna