Cell-free DNA next-generation sequencing successfully detects infectious pathogens in pediatric oncology and hematopoietic stem cell transplant patients at risk for invasive fungal disease.
Amy E ArmstrongJenna RossoffDesiree HollemonDavid K HongWilliam J MullerSonali ChaudhuryPublished in: Pediatric blood & cancer (2019)
cfDNA NGS detected fungal pathogens from blood confirming its potential to guide treatment decisions in pediatric patients at risk for IFD and limit excessive empiric antifungal use. Future studies are needed to better understand the sensitivity and specificity of this approach.
Keyphrases
- hematopoietic stem cell
- end stage renal disease
- ejection fraction
- newly diagnosed
- gram negative
- palliative care
- prognostic factors
- peritoneal dialysis
- candida albicans
- copy number
- gene expression
- current status
- patient reported outcomes
- weight gain
- young adults
- physical activity
- combination therapy
- cell wall
- circulating tumor cells