Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.
Lucy E BradshawRachel H HainesKim S ThomasJoanne R ChalmersAlan D IrvineHywel C WilliamsSara J BrownPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Trained observers were able to define palmar hyperlinearity in the majority (3191/3656, 87%) of cases. The presence of HLP is not a reliable sign to detect FLG mutations, but the absence of HLP excludes FLG null genotype with a reasonable degree of certainty.
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