Periodontal pathogen Aggregatibacter actinomycetemcomitans JP2 correlates with colonic leukocytes decrease and gut microbiome imbalance in mice.
André Luiz A CostaMariana Alves SoaresTalita Gomes Baeta LourenςoKamila Guimarães-PintoAlessandra D FilardyAdriana Miranda de OliveiraD'Angelo Carlo MaglianoD' Angelo Carlo MaglianoOlga Maria Oliveira de AraújoLarissa MouraRicardo Tadeu LopesAna Luísa Palhares MirandaJorge Luiz Mendonça TributinoAna Paula Vieira ColomboPublished in: Journal of periodontal research (2024)
Based on this model, intragastric administration of Aa JP2 is associated with changes in the gut ecosystem of healthy hosts, characterized by less live/recruited myeloid cells, enrichment of the gut microbiota with pathobionts and decrease in commensals. Negligible levels of colonic pro-inflammatory cytokines, and no signs of mucosal barrier disruption were related to these changes.
Keyphrases
- ulcerative colitis
- induced apoptosis
- cell cycle arrest
- climate change
- bone marrow
- acute myeloid leukemia
- dendritic cells
- high fat diet induced
- peripheral blood
- endoplasmic reticulum stress
- candida albicans
- type diabetes
- human health
- cell death
- adipose tissue
- immune response
- insulin resistance
- cell proliferation
- drug induced