Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules.
Anneli KruveKenji CapriceRoy LavendommeJan M WollschlägerStefan SchoderHendrik V SchröderJonathan R NitschkeFabien B L CougnonChristoph A SchalleyPublished in: Angewandte Chemie (International ed. in English) (2019)
A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.
Keyphrases
- tandem mass spectrometry
- gas chromatography
- solid phase extraction
- liquid chromatography
- high performance liquid chromatography
- mass spectrometry
- ultra high performance liquid chromatography
- high resolution
- simultaneous determination
- high resolution mass spectrometry
- molecularly imprinted
- loop mediated isothermal amplification
- high glucose
- diabetic rats
- oxidative stress
- drug induced
- ionic liquid
- capillary electrophoresis
- bioinformatics analysis
- endothelial cells