Numerous innovative granulation techniques utilizing the concept of liquid marbles have been proposed before. However, these processes frequently encounter issues such as collisions, aggregation, and fragmentation of liquid/melt marble during the granulation process. In this study, the oriented superhydrophobic surface (OSS) was successfully prepared by utilizing copper wire to solve the above problem, facilitating efficient batch production and guided transportation of uniform marbles. The parameters and mechanisms of this process were thoroughly studied. The optimized structure is that the copper wire spacing ( d ) and height ( h ) are set as 1.0 and 0.1 mm, respectively. This resulted in a surface contact angle (CA) of 156° and anisotropic sliding (Δ SA ) of 16.3 ± 1.34°. Using the prepared substrate, high-quality urea products were successfully obtained through the controlled transport of urea melt marbles. The mechanism of guided and directional drag reduction, based on the solid/solid contact on the surface, is proposed. These findings in this study have significant implications for improving granulation processes.