CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility.

Julia SeyfarthHeinz AhlertJoachim RosenbauerChristina BaechleMichael RodenReinhard W HollErtan MayatepekThomas MeissnerMarc Jacobsen

Published in: Molecular and cellular pediatrics (2018)

This study provides no evidence for an association of CISH promoter SNPs with susceptibility to T1D or severity of disease. In contrast to previous studies, no influence of different haplotypes on CIS mRNA expression or T cell-mediated functions was found.

Keyphrases

type diabetes
dna methylation
transcription factor
gene expression
magnetic resonance
cardiovascular disease
glycemic control
metabolic syndrome
case control
weight loss