The Effect of ABCB1 and CES1 Polymorphisms on Plasma Levels of Dabigatran and Risk of Hemorrhagic Complications in Ischemic Stroke Patients.
Anna OlšerováPetr JanskýHana MagerováTereza ŠrámkováPetra KešnerováSilvia KmetonyováVlastimil ŠulcHana HalmováMartin ŠrámekIvana ŠarbochováJaroslava Paulasová-SchwabováKateřina BenešováJan MacekVáclav MaťoškaAleš TomekPublished in: American journal of therapeutics (2024)
The CES1 variant genotype rs2244613 is closely linked with reduced c min of dabigatran. Carriers of the ABCB1 rs4148738 polymorphism exhibit a tendency toward higher plasma levels of dabigatran, which leads to a significantly increased risk of bleeding.