The digital revolution has significantly altered healthcare, including communicable disease control, with online spaces emerging as vital tools in preventing, identifying and controlling the spread of diseases. However, healthcare professionals, including nurses, need to find a balance between harnessing the benefits of mass communication and mitigating the potentially harmful effects of online misinformation. This article explores the benefits and challenges of using online spaces such as social media platforms in the control of communicable diseases and discusses the potential use of telehealth in reducing the risk of healthcare-associated infection and antimicrobial resistance. The author also describes a framework that nurses can use to explore potential roles and practice in the context of communicable disease control in online spaces.